The route of the 101st edition is basically flat except for the crossing of Monferrato where a series of short climbs will be faced. After departing from Mesero it crosses Magenta before continuing along the Po Valley on wide and straight roads. In addition to the usual city obstacles such as roundabouts, traffic islands and raised sections, there are four level crossings, all concentrated in the first 60km. After crossing the Po near Valenza, the route takes in the undulations of Monferrato, before crossing Asti.
The final 70km are practically flat to the finish in Stupinigi.
The route’s last 5km are mostly flat or slightly uphill on medium width city roads including a series of roundabouts. The last corner is 400m from the finish.