A very bumpy stage with a difficult climb in the finale. From Torricella Sicura, past km 0 in Teramo at the end of the opening descent, the route is an endless succession of climbs and descents, linked without pause for breath. The stage passes through some of the most popular locations of the Race of the Two Seas, such as Castellalto and Bellante, and some from the recent past such as Campli and Civitella del Tronto. The route is very demanding in both course and profile, and it runs mainly on slightly worn roads. After Villa Lempa, the peloton climbs to San Giacomo from the eastern side (12 km at an average 6.2%) and then descends into the Castellano valley, taking in 10 km of flat roads beside the lake.
The last kilometres are flat until about 1,000 metres to go, where the home straight begins, with an average gradient of around 7% and slightly higher peaks.